J3205
Sigma
JNJ-1661010 
≥98% (HPLC)
| Linear Formula: | C19H19N5OS |
| Molecular Weight: | 365.45 |
| MDL number: | MFCD00209157 |
Description
| Biochem/physiol Actions | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with >100-fold preferentially selective for FAAH-1 over FAAH-2. FAAH in an integral membrane enzyme within the amidase-signature family. It catalyzes the hydrolysis of several endogenous biologically active lipids and involves in a variety of physiological and pathological processes, including synaptic regulation, regulation of sleep and feeding, locomotor activity, pain and inflammation. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: ≥28 mg/mL |
| storage temp. | 2-8°C |
Safety
| WGK Germany | 1 |
References
| reference | Karbarz MJ , et al., Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase Anesth. Analg. 108, 316-329, (2009) |
| John M. Keith , et al., Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase Bioorg. Med. Chem. Lett. 18, 4838, (2008) |
